A young woman grieving the loss of her mother, a famous scream queen from the 1980s, finds herself pulled into the world of her mom's most famous movie. Reunited, the women must fight off the film's maniacal killer.

College student Ryan wakes up in his car on Tuesday, September 19. Returning to his dorm room, he walks in on his roommate Carter and Carter's girlfriend Tree. He resumes work on an experimental quantum reactor with fellow students Samar and Dre. After Bronson, the school dean, shuts down the project for triggering several power outages, Ryan is murdered by someone dressed as Babyface, and wakes up again on Tuesday the 19th. Tree explains her experience Happy Death Day#Plot, and she and Carter agree to help Ryan. They learn the reactor was responsible for creating the loop. The new Babyface tracks Ryan down, but Tree subdues and unmasks him to reveal another Ryan. The second Ryan warns that the original must die for the loop to close. Terrified, Ryan activates the reactor, releasing a powerful energy pulse that knocks everyone unconscious.

In a California desert town, a short-order cook with clairvoyant abilities encounters a mysterious man with a link to dark, threatening forces.